Humira (adalimumab)

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Humira is used to reduce the signs and symptoms of moderately to severely active rheumatoid arthritis (RA), polyarticular juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and and a chronic skin condition called hidradenitis suppurativa.

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Description

What is Humira?

Humira is a medication to help relieve pain and inflammation in your body. This pain may be from conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. You may also be prescribed Humira to treat Crohn’s disease and ulcerative colitis if other medications have been tried without success. Your doctor may also prescribe Humira for reasons not listed in this medication guide.

 

How should I use Humira?

Use Humira exactly as prescribed by your doctor. Follow the directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Use Humira regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

The dose schedule for Humira is highly variable and depends on the condition you are treating. You may need an injection only every other week. Or you may need up to 4 injections in 1 day for 2 days in a row. Follow your doctor’s dosing instructions very carefully.

Do not start using Humira if you have any signs of an infection (fever, chills, night sweats, weight loss, body aches, tiredness, cough with mucus, feeling short of breath, skin sores, stomach pain, diarrhea, pain or burning when you urinate). Call your doctor for instructions.

Humira is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Do not inject Humira into skin that is bruised, red, tender, or hard.

Each prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. Do not use a prefilled syringe if the medicine if it looks cloudy or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Adalimumab can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Serious and sometimes fatal infections may occur during treatment with Humira. Contact your doctor right away if you have signs of infection such as: fever, chills, sore throat, or flu symptoms.

If you need surgery, tell the surgeon ahead of time that you are using Humira.

If you have ever had hepatitis B, Humira can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.

Store in a refrigerator. If you travel with a prefilled syringe, keep it in a small cooler with an ice pack and protect it from light. Do not remove the prefilled syringe from the refrigerator or cooler until you are ready to give yourself an injection.

Do not freeze, and throw away the medicine if it has become frozen.

Humira dosing information
Usual Adult Dose of Humira for Ankylosing Spondylitis:

40 mg subcutaneously every other week

In some patients not taking concomitant methotrexate, the dosing interval may be increased to 40 mg every week.

Methotrexate, glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, analgesics, or other disease modifying agents may be given concomitantly.

Usual Adult Dose for Rheumatoid Arthritis:

40 mg subcutaneously every other week

In some patients not taking concomitant methotrexate, the dosing interval may be increased to 40 mg every week.

Methotrexate, glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, analgesics, or other disease modifying agents may be given concomitantly.

Usual Adult Dose of Humira for Psoriatic Arthritis:

40 mg subcutaneously every other week

In some patients not taking concomitant methotrexate, the dosing interval may be increased to 40 mg every week.

Methotrexate, glucocorticoids, salicylates, nonsteroidal anti-inflammatory drugs, analgesics, or other disease modifying agents may be given concomitantly.

Usual Adult Dose for Crohn’s Disease — Acute:

Initial dose: 160 mg subcutaneously on Day 1.
The initial dose may be given as 4 injections on Day 1, or as 2 injections per day for 2 consecutive days (Days 1 and 2).
Week 2: 80 mg subcutaneously on Day 15.
Maintenance dose: Beginning week 4 (Day 29), 40 mg every other week.

Aminosalicylates, corticosteroids, and/or immunomodulatory agents may be continued during treatment with adalimumab.

The use of adalimumab for Crohn’s disease beyond one year had not been evaluated in controlled clinical studies.

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1 Pack – $2000, 2 Packs – $4000, 3 Packs – $5500

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